Alessandra Bulbarelli
Position
Assistant professor in BIOCHEMISTRY at the University of Milano-Bicocca, Department of Medicine and Surgery.
Research activities and skills
Her research field includes study of cellular and molecular mechanisms involved in Alzheimer’s disease onset using neuronal cellular models.
She has sound experience in cell viability and cytotoxicity assays in chemical and drug screening projects.
Most Relevant Publication
Farina F, Lonati E, Brambilla A, Dal Magro R, Milani C, Botto L, Sancini G, Palestini P, Bulbarelli A. Diesel exhaust particles (DEP) pre-exposure contributes to the anti-oxidant response impairment in hCMEC/D3 during post-oxygen and glucose deprivation damage. Toxicol Lett. 2017 May 15;274:1-7. doi: 10.1016/j.toxlet.2017.04.003. Epub 2017 Apr 8. PubMed PMID: 28400208.
Ferrazzano L, Viola A, Lonati E, Bulbarelli A, Musumeci R, Cocuzza C, Lombardo M, Tolomelli A. New isoxazolidinone and 3,4-dehydro-β-proline derivatives as antibacterial agents and MAO-inhibitors: A complex balance between two activities. Eur J Med Chem. 2016 Nov 29;124:906-919. doi: 10.1016/j.ejmech.2016.09.007. Epub 2016 Sep 4. PubMed PMID: 27676470.
Farina F, Milani C, Botto L, Lonati E, Bulbarelli A, Palestini P. Involvement of MEK-ERK1- 2 pathway in the anti-oxidant response in C6 glioma cells after diesel exhaust particles exposure. Toxicol Lett. 2016 May 27;250-251:57- 65. doi: 10.1016/j.toxlet.2016.04.008. Epub 2016 Apr 19. PubMed PMID: 27091075.
Brambilla A, Lonati E, Milani C, Rizzo AM, Farina F, Botto L, Masserini M, Palestini P, Bulbarelli A. Ischemic conditions and ß-secretase activation: The impact of membrane cholesterol enrichment as triggering factor in rat brain endothelial cells. Int J Biochem Cell Biol. 2015 Dec;69:95-104. PubMed PMID: 27022655.
Fortuna CG, Berardozzi R, Bonaccorso C, Caltabiano G, Di Bari L, Goracci L, Guarcello A, Pace A, Palumbo Piccionello A, Pescitelli G, Pierro P, Lonati E, Bulbarelli A, Cocuzza CE, Musumarra G, Musumeci R. New potent antibacterials against Gram-positive multiresistant pathogens: effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles. Bioorg Med Chem. 2014 Dec 15;22(24):6814-25. doi: 10.1016/j.bmc.2014.10.037. Epub 2014 Nov 1. PubMed PMID: 25464880.
Lonati E, Brambilla A, Milani C, Masserini M, Palestini P, Bulbarelli A. Pin1, a new player in the fate of HIF- 1α degradation: an hypothetical mechanism inside vascular damage as Alzheimer's disease risk factor. Front Cell Neurosci. 2014 Jan 17;8:1. doi: 10.3389/fncel.2014.00001. eCollection 2014. PubMed PMID: 24478626; PubMed Central PMCID: PMC3894457.