Elena Sacco


Assistant Professor in Biochemistry at the University of Milano-Bicocca.

Research activities and skills

-Analysis of potency, selectivity and action mechanism of food-derived extracts / small molecules, on purified clinical targets, preclinical 2D and 3D cellular models -Multiparametric analysis in mammalian cells exposed to food-derived extracts / small molecules (effect on viability, proliferation, migration, energy and redox metabolism)

Most Relevant Publication

Palmioli, A., Ciaramelli, C., Tisi, R.A., Spinelli, M., De Sanctis, G., Sacco, E., Airoldi C. 2017 Natural compounds in cancer prevention: effects of coffee extracts and their main polyphenolic component 5-CQA on oncogenic Ras proteins. Chemistry - An Asian Journal, 12(18), 2457-2466.

Tisi, R., Gaponenko, V., Vanoni, M., Sacco, E. (2020) Natural Products Attenuating Biosynthesis, Processing, and Activity of Ras Oncoproteins: State of the Art and Future Perspectives. Biomolecules. 2020 Nov 10;10(11):1535.

Pasquale, V., Ducci, G., Campioni, G., Ventrici, A., Assalini, C., Busti, S., Vanoni, M., Vago, R., Sacco E. (2020) Profiling and Targeting of Energy and Redox Metabolism in Grade 2 Bladder Cancer Cells with Different Invasiveness Properties. Cells. 2020 Dec 11;9(12):2669.

Raggi, C., Taddei, M. L., Sacco, E., Navari, N., Correnti, M., Piombanti, B., Pastore, M., Jorio, J., Lori, G., Lewinska, M., Andersen, J.B., Ramazzotti, M., Orlandi, I., Chiarugi, P., Marra F. (2021) Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma J Hepatol. 2021 Jan 20:S0168-8278(21)00024-6.

Tisi, R., Spinelli, M., Palmioli, A., Airoldi, C., Cazzaniga, P., Besozzi, D., Nobile, M.S., Mazzoleni, E., Arnhold, S., De Gioia, L., Grandori, R., Peri, F., Vanoni, M., Sacco E. (2021) The multi-level mechanism of action of a pan-Ras inhibitor explains its antiproliferative activity on Cetuximab-resistant cancer cells Frontiers in Molecular Biosciences, section Molecular Diagnostics and Therapeutics. Front. Mol. Biosci., 17 February 2021 | https://doi.org/10.3389/fmolb.2021.625979.