Ferdinando Chiaradonna
Position
Assistant professor in Biochemistry at the Department of Biotechnology and Biosciences, University Milano-Bicocca, Milan.
Research activities and skills
His main research interests are focused on the role of metabolism in cancer onset, progression and maintenance, with the aim to identify altered metabolic pathways to be used in early diagnosis and for precise medicine. In recent times he has been interested in synthesis of novel compounds specifically inhibiting tumor growth by metabolic targeting.
Most Relevant Publication
Palorini R, Votta G, Pirola Y, De Vitto H, De Palma S, Airoldi C, Vasso M, Ricciardiello F, Lombardi PP, Cirulli C, Rizzi R, Nicotra F, Hiller K, Gelfi C, Alberghina L, Chiaradonna F. Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis. PLoS Genet. 2016 Mar 15;12(3).
Chiaradonna F, Barozzi I, Miccolo C, Bucci G, Palorini R, Fornasari L, Botrugno OA, Pruneri G, Masullo M, Passafaro A, Galimberti VE, Fantin VR, Richon VM, Pece S, Viale G, Di Fiore PP, Draetta G, Pelicci PG, Minucci S, Chiocca S. Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer. Antioxid Redox Signal. 2015 Jul 1;23(1):15-29.
Chiaradonna F, Cirulli C, Palorini R, Votta G, Alberghina L. New insights in the connection between HDACs, cell metabolism and cancer. Antioxid Redox Signal. 2015 Jul 1;23(1):30-50.
Palorini R, Cammarata FP, Balestrieri C, Monestiroli A, Vasso M, Gelfi C, Alberghina L, Chiaradonna F*. Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein response. Cell Death Dis. 2013 Jul 18;4:e732.
Palorini R, Simonetto T, Cirulli C, Chiaradonna F. Mitochondrial complex I inhibitors and forced oxidative phosphorylation synergize in inducing cancer cell death. Int J Cell Biol. 2013;2013:243876.
Gaglio D, Metallo CM, Gameiro PA, Hiller K, Danna LS, Balestrieri C, Alberghina L, Stephanopoulos G, Chiaradonna F. Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Mol Syst Biol. 2011 Aug 16;7:523.