Sonia Colombo
Position
Assistant professor in Molecular Biology at the University Milano-Bicocca.
Research activities and skills
Stress resistance (e.g. oxidative and osmotic stress), apoptosis, cell cycle regulation and molecular mechanisms of signal transduction in eukaryotes, in particular in the yeast Saccharomyces cerevisiae. Yeast models can play an important role, since the findings in yeast can be interpolated to humans. She is also involved in single cell techniques to study signal transduction pathways. Molecular and cellular biology techniques and flow cytometry assays are some of the approaches used in her laboratory.
Most Relevant Publication
Amigoni L., Frigerio G., Martegani E., Colombo S. “Involvement of Aif1 in apoptosis triggered by lack of Hxk2 in the yeast Saccharomyces cerevisiae” (2016), FEMS Yeast Research, pii: fow016. doi: 10.1093/femsyr/fow016. Epub 2016 Feb 18.
Amigoni L., Colombo S., Belotti F., Alberghina L., Martegani E. “The transcription factor Swi4 is target for PKA regulation of cell size at the G1 to S transition in Saccharomyces cerevisiae” (2015), Cell Cycle, 14 (15), 2429-2438.
Colombo S., Paiardi C., Pardons K., Winderickx J., Martegani E. “Evidences for Adenylate Cyclase as a scaffold protein for Ras2-Ira interaction in Saccharomyces cerevisie” (2014), Cellular Signalling, 26, 1147–1154.
Colombo, S. and Martegani, E. “ Methods to Study the Ras2 Protein Activation State and the Subcellular Localization of Ras GTP in Saccharomyces cerevisiae ” In Ras Signaling –Methods and protocols- Methods in Molecular Biology, Vol. 1120, Trabalzini L. and Retta S.F. (Eds.), 2014- Humana Press.
Broggi S., Martegani E., Colombo S. “Nuclear Ras2-GTP Controls Invasive Growth in Saccharomyces cerevisiae “ (2013), PlosOne, 8(11):e79274. doi: 10.1371/journal.pone.0079274.
Amigoni L., Martegani E., Colombo S. “Lack of HXK2 Induces Localization of Active Ras in Mitochondria and Triggers Apoptosis in the Yeast Saccharomyces cerevisiae,” Oxidative Medicine and Cellular Longevity, (2013), 2013:678473. doi: 10.1155/2013/678473. Epub 2013 Sep 5.
Broggi S., Martegani E., Colombo S. “Live-Cell Imaging of Endogenous Ras-GTP Shows Predominant Ras Activation at the Plasma Membrane and in the Nucleus in Saccharomyces cerevisiae” (2013) International Journal of Biochemistry & Cell Biology, 45, 384-394.