Silvia Mugnano
Position
Full Professor of Genetics at the University of Milano-Bicocca.
Research activities and skills
Research field includes the study of the molecular mechanisms that protect the integrity of telomeres and genomes to provide a better understanding of the diseases (i.e. premature aging, cancer, neurodegeneration, sterility) that can arise when such protection is lost.
Most Relevant Publication
Cesena D, Cassani C, Rizzo E, Lisby M, Bonetti D, Longhese MP. 2017. Regulation of telomere metabolism by the RNA processing protein Xrn1. Nucleic Acids Res. 45, 3860-3874.
Cassani C, Gobbini E, Wang W, Niu H, Clerici M, Sung P, Longhese MP. 2016. Tel1 and Rif2 regulate MRX functions in end-tethering and repair of DNA double-strand breaks. PLoS Biol. 14, e1002387.
Manfrini N, Clerici M, Wery M, Colombo CV, Descrimes M, Morillon A, d'Adda di Fagagna F, Longhese MP. 2015. Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae. Elife 4. doi: 10.7554/eLife.08942.
Rossiello F, Herbig U, Longhese MP, Fumagalli M, d'Adda di Fagagna F. 2014. Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing. Curr. Opin. Genet. Dev. 26, 89-95.
Gobbini E, Trovesi C, Cassani C, Longhese MP. 2014. Telomere uncapping at the crossroad between cell cycle arrest and carcinogenesis. Mol. Cell. Oncol. 1, e29901.